Use cases

Built for teams where
precision matters.

From Phase I to NDA. From clinical biostatistics to SAS migration. Reprosia scales with your regulatory obligation and clinical programme complexity.

Pharma & Biotech

Clinical trial statistical analysis

Phase I
Phase II
Phase III
NDA/BLA

Reproducible SAPs, locked environments at database freeze, automated audit trails for DSMB and regulatory review. Reprosia ensures your primary, secondary, and sensitivity analyses are reproducible from first draft to final submission.

Before
  • Ad-hoc R scripts
  • Manual version tracking
  • Undocumented packages
  • Audit failures at submission
After
  • Certified R environment
  • Automatic audit trail
  • Locked package versions
  • Submission-ready output
21 CFR Part 11ICH E9(R1)DSMB
Regulatory Affairs

Submission-ready R package validation

Validate your R environment to FDA and EMA standards before submission. Generate complete IQ/OQ/PQ documentation automatically. Reduce the risk of submission audit failures from undocumented package dependencies or missing validation evidence.

  • Automated IQ/OQ/PQ report generation
  • Package version provenance documentation
  • Electronic signatures for validation records
  • Pre-submission validation checklist
  • Regulatory reviewer-ready documentation format
IQ/OQ/PQFDAEMAeCTD
Contract Research Organisations

Multi-sponsor reproducibility management

Manage reproducibility and compliance across multiple sponsor environments and data governance frameworks. Deliver consistent, validated analyses regardless of client infrastructure, internal tooling, or regulatory jurisdiction.

  • Sponsor-specific environment profiles
  • Cross-site validation harmonisation
  • Sponsor audit trail handover packages
  • Multi-environment drift detection
  • White-label documentation for sponsor submission
Multi-sponsorGCPCross-site
SAS → R Migration

Regulated environment transition without compliance risk

Migrate from SAS to R without losing compliance posture or regulatory confidence. Reprosia provides automated equivalence testing, parallel validation, and complete migration audit trails acceptable for agency review — supporting teams at every phase of the transition.

SAS environment
  • Legacy PROC code
  • Proprietary formats
  • High licensing cost
  • Limited reproducibility
R with Reprosia
  • Open-source R
  • Equivalence certified
  • Full audit trail
  • Agency-acceptable
Equivalence testingMigration auditGxP
Bayesian Analysis · FDA 2026

Prior elicitation and regulatory justification

Structured Bayesian prior elicitation, conflict diagnostics, and regulatory-ready prior justification reports. Aligned with the FDA 2026 draft guidance on Bayesian methods for drug and biological products.

  • SHELF-style elicitation across 6 distribution families
  • Prior-data conflict diagnostics and sensitivity analysis
  • Submission-ready prior justification reports
baypriorFDA 2026
Phase I–IV

Clinical trial statistical analysis

Reproducible SAPs across all clinical trial phases. Locked environments at database freeze, automated DSMB audit trails, and NDA/BLA-ready submission packages.

  • Statistical Analysis Plan implementation
  • Database lock environment snapshot
  • DSMB reporting with full audit trail
  • Sensitivity analysis reproducibility
Biomarker & Translational

Biomarker analysis reproducibility

Ensure biomarker analyses supporting companion diagnostic development and patient selection strategies are reproducible, auditable, and defensible in regulatory review.

  • Biomarker assay data provenance
  • Pre-specified analysis audit trail
  • Post-hoc analysis flagging
  • CDx regulatory package support
Regulatory Affairs

Pre-submission R validation

Complete R environment validation before submission. IQ/OQ/PQ documentation, electronic records, and system validation evidence — automatically generated and ready for regulatory review.

  • FDA 21 CFR Part 11 compliance evidence
  • EMA Annex 11 documentation
  • Computerised System Validation (CSV) support
  • Risk-based validation approach documentation
Submissions

eCTD statistical output packaging

Generate eCTD-ready statistical output packages from your R analyses. Module 5 outputs, define.xml, reviewer's guide — all with full traceability to source data and analysis code.

  • CDISC SDTM and ADaM dataset generation
  • Define.xml and reviewer's guide production
  • Module 5 output table formatting
  • ISS/ISE dataset integration
CRO Operations

Multi-sponsor environment management

Manage distinct validated R environments per sponsor. Reprosia isolates sponsor environments while providing central oversight of validation status and compliance posture.

  • Sponsor-isolated validated environments
  • Central validation status dashboard
  • Sponsor-specific audit trail export
  • Contract-specific documentation branding
Multi-Centre Trials

Cross-site reproducibility assurance

Guarantee identical outputs from multiple statistical sites. Reprosia synchronises environments across sites and flags any deviation before it reaches the submission package.

  • Cross-site environment synchronisation
  • Multi-site drift alerts
  • Independent verification workflow
  • Double-programming support
SAS → R

Equivalence-certified migration

Migrate SAS macros and PROC code to R with automated equivalence testing. Reprosia compares outputs numerically and documents any differences with regulatory-acceptable justification.

  • Automated output comparison (numerical tolerance)
  • Difference documentation with justification
  • Migration audit trail for agency review
  • Risk-based validation scope definition
Team Transition

Compliance-safe upskilling pathway

Support your statistical programming team in transitioning to R without compromising compliance obligations. Reprosia provides guardrails, validation, and training integration throughout.

  • Staged migration timeline support
  • Parallel SAS/R validation period
  • Compliance guardrails for R novices
  • Training integration and competency evidence
Bayesian Clinical Trials · FDA 2026

Prior elicitation and regulatory justification

The FDA 2026 draft guidance on Bayesian statistical methods raises the bar for prior justification. Reprosia integrates bayprior to provide structured elicitation workflows, conflict diagnostics, and regulatory-ready prior justification reports directly in your submission package.

  • SHELF-style quantile matching and moment matching across 6 distribution families
  • Prior-data conflict diagnostics (Box p-value, Bhattacharyya overlap, KL divergence)
  • Sensitivity analysis with tornado plots and influence heatmaps
  • Self-contained prior justification reports (HTML, PDF, Word) for regulatory submission
FDA 2026 guidancebaypriorICH E9(R1)
Adaptive & Informative Designs

Historical data borrowing with power priors

Leverage historical control data or prior trial evidence in your Bayesian design with principled, audit-ready methodology. Reprosia supports robust mixture priors, power priors, and sceptical priors — each with complete documentation for regulatory review.

  • Calibrated power priors via Bayes Factor optimisation
  • Robust mixture priors (Schmidli et al.) for MAP borrowing
  • Sceptical priors for regulatory sensitivity analyses
  • Expert opinion pooling with Bhattacharyya agreement diagnostics
Power priorMAP priorAdaptive design
Who we serve

Every role in the
regulated R ecosystem.

STAT

Clinical Biostatisticians

Focus on the science. Reprosia handles environment documentation, audit trails, and reproducibility so your team writes statistics, not validation SOPs.

PROG

Statistical Programmers

Locked environments, certified packages, and automated validation reports. Ship analysis code you can stand behind at a regulatory inspection.

REG

Regulatory Affairs

Complete IQ/OQ/PQ documentation generated automatically. Submission-ready evidence packages that satisfy FDA and EMA reviewer expectations.

QA

Quality Assurance

Real-time compliance monitoring, audit trail access, and validation status dashboards. Catch issues before they reach the inspection.

CTO

R&D Leadership

Platform-level visibility into your statistical computing compliance posture. Reduce submission risk and accelerate approval timelines.

IT

R&D IT / Validation

Computerised system validation evidence generated automatically. Integrate Reprosia with existing GxP IT infrastructure and change control processes.

Consulting services

Expert support for
regulated R environments.

We work directly with pharma, biotech, and CRO teams to implement reproducible, compliant R infrastructure. Every engagement is hands-on, led by the founder.

01

Regulatory R implementation

End-to-end implementation of R in GxP environments. Validation strategy, SOPs, system validation, and ongoing compliance support.

02

Reproducibility audits

Independent audit of your R analysis pipeline. We identify reproducibility risks and compliance gaps, with a prioritised remediation roadmap.

03

IQ/OQ/PQ validation

Validation of R and R packages to pharmaceutical industry standards. Full qualification documentation acceptable for FDA and EMA review.

04

Estimand specification

ICH E9(R1) estimand strategy for your clinical trial programme — from protocol definition to SAP implementation.

05

SAS 2192 R migration

Structured migration from SAS to R in regulated environments. Equivalence testing, validation bridging, and compliance throughout.

06

Bayesian trial support

Prior elicitation, conflict diagnostics, and FDA 2026 Bayesian guidance implementation using the bayprior framework.

Get started

Tell us about
your use case.

Every engagement starts with a conversation. We'll understand your environment and show you exactly how Reprosia fits.

Or email us at team@reprosia.com