AI-native pharma R&D platform

R&D intelligence
that holds up.

Reprosia brings AI-driven rigor to pharmaceutical research — from first analysis to regulatory submission. Built on open-source foundations. Designed for compliance-first teams.

21 CFR
Part 11 compliant
ICH E9
R1 estimand framework
Full
Audit trail coverage
5
Open-source packages
The problem

Pharma R&D has a
reproducibility crisis.

Reproducibility in clinical analyses is harder than it should be. Environments drift, dependencies go undocumented, and the gap between analysis and submission is rarely as traceable as regulators expect. Reprosia is built to close that gap.

~70%
of preclinical studies cannot be reproduced by independent teams — billions in wasted R&D investment annually.
$50B+
estimated annual cost of irreproducible research in biomedical sciences, including failed regulatory submissions.

Regulatory agencies are tightening requirements. FDA and EMA now expect documented, auditable, reproducible analyses as standard — not exception.

Most teams rely on ad-hoc R scripts, undocumented environments, and manual validation processes that break at submission time. The cost is measured in delayed approvals, failed audits, and lost competitive advantage.

Reprosia automates the infrastructure of rigor — so your team can focus on the science, not the paperwork.

21 CFR Part 11 ICH E9(R1) GxP CDISC eCTD EMA
The platform

Three pillars of
analytical integrity.

Not a reporting tool. The infrastructure layer that makes pharmaceutical analyses trustworthy from day one. Explore the platform →

VAL

Validate

AI-assisted IQ/OQ/PQ validation of your R environment. Continuous audit trails compliant with 21 CFR Part 11. Every function call documented automatically.

  • 21 CFR Part 11 audit trail
  • Package qualification (IQ/OQ/PQ)
  • System validation reports
REP

Reproduce

Locked package versions, containerised execution, drift detection. Your results today match your results at submission — regardless of environment or time.

  • Environment lockfiles
  • Drift detection alerts
  • Cross-environment validation
SUB

Submit

Regulatory-ready outputs for FDA and EMA. CDISC-compatible structures, ICH E9(R1) estimand documentation, eCTD-ready packages.

  • SDTM & ADaM outputs
  • Estimand specification docs
  • eCTD submission packages
Use cases

Built for teams where
precision matters.

From Phase I to NDA. From clinical biostatistics to SAS migration. See all use cases →

Pharma & Biotech

Clinical trial statistical analysis

Reproducible SAPs, locked environments at database freeze, automated audit trails for DSMB and regulatory review. From Phase I to NDA/BLA.

Learn more →
Regulatory Affairs

Submission-ready R packages

Validate your R environment to agency standards. Generate IQ/OQ/PQ documentation automatically. Reduce submission audit risk significantly.

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CRO Teams

Multi-sponsor reproducibility

Consistent validation across multiple sponsor environments. Deliver reproducible analyses regardless of client infrastructure.

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SAS → R Migration

Regulated environment transition

Migrate from SAS to R without losing compliance posture. Automated equivalence testing and parallel validation.

Learn more →
Early access

Ready to make your R analyses
regulation-ready?

Reprosia is in private early access. We are working with a small number of pharma and biotech teams to shape the platform.

Or reach us at team@reprosia.com